ARG82167
Glutathione S-transferase Activity Assay Kit (Colorimetric)
Glutathione S-transferase Activity Assay Kit (Colorimetric) for Functional study and Human,Mouse,Rat,All species
Overview
| Product Description | ARG82167 Glutathione S-transferase Activity Assay Kit (Colorimetric) can be used to measure Glutathione S-transferase activity in cell lysates and tissues. |
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| Tested Reactivity | Hu, Ms, Rat, All |
| Tested Application | FuncSt |
| Target Name | Glutathione S-transferase |
| Conjugation Note | Read at 340 nm |
| Sensitivity | 2 U/L |
| Detection Range | 2 - 80 U/L |
| Sample Type | cell lysates and tissues |
| Sample Volume | 20 µl |
| Alternate Names | GST HB subunit 4; MU-1; GST class-mu 1; GST1; Glutathione S-transferase Mu 1; GSTM1-1; GSTM1a-1a; MU; GTH4; EC 2.5.1.18; GSTM1b-1b; H-B; GTM1 |
Application Instructions
| Application Note | Please note that this kit does not include a microplate. |
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| Assay Time | 10 min |
Properties
| Form | Liquid |
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| Storage Instruction | Store the kit at 2-8°C. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GSTM1 |
| Gene Full Name | glutathione S-transferase mu 1 |
| Background | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. [UniProt] |
| Cellular Localization | Cytoplasm. [UniProt] |
| Title | Download Link |
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| ARG82167 Glutathione S-transferase Activity Assay Kit (Colorimetric) User manual |
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