ARG81942

Human ACVRL1 ELISA Kit

Human ACVRL1 ELISA Kit for ELISA and Human

Component

Cat No Component Name Package Temp
ARG81942-001 Antibody-coated microplate 8 X 12 strips 4°C. Unused strips should be sealed tightly in the air-tight pouch.
ARG81942-002 Standard 2 X 10 ng/vial 4°C
ARG81942-003 Standard/Sample diluent 30 ml (Ready to use) 4°C
ARG81942-004 Antibody conjugate concentrate (100X) 1 vial (100 µl) 4°C
ARG81942-005 Antibody diluent buffer 12 ml (Ready to use) 4°C
ARG81942-006 HRP-Streptavidin concentrate (100X) 1 vial (100 µl) 4°C
ARG81942-007 HRP-Streptavidin diluent buffer 12 ml (Ready to use) 4°C
ARG81942-008 25X Wash buffer 20 ml 4°C
ARG81942-009 TMB substrate 10 ml (Ready to use) 4°C (Protect from light)
ARG81942-010 STOP solution 10 ml (Ready to use) 4°C
ARG81942-011 Plate sealer 4 strips Room temperature

Overview

Product Description ARG81942 Human ACVRL1 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human ACVRL1 in serum, plasma (heparin, EDTA) and cell culture supernatants.
Tested Reactivity Hu
Tested Application ELISA
Specificity There is no detectable cross-reactivity with other relevant proteins.
Target Name ACVRL1
Conjugation HRP
Conjugation Note Substrate: TMB and read at 450 nm.
Sensitivity 23.45 pg/ml
Sample Type Serum, plasma (heparin, EDTA) and cell culture supernatants.
Standard Range 46.9 - 3000 pg/ml
Sample Volume 100 µl
Precision Intra-Assay CV: 5.1%; Inter-Assay CV: 5.6%
Alternate Names ACVRLK1; ALK1; ORW2; ALK-1; HHT; EC 2.7.11.30; Serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; HHT2; SKR3; TSR-I; Activin receptor-like kinase 1

Application Instructions

Assay Time ~ 5 hours

Properties

Form 96 well
Storage Instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 94 Human ACVRL1

Swiss-port # P37023 Human Serine/threonine-protein kinase receptor R3

Gene Symbol ACVRL1
Gene Full Name activin A receptor type II-like 1
Background This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
Function Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. [UniProt]
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Title Download Link
ARG81942 Human ACVRL1 ELISA Kit User manual download icon Download