ARG83333
Human CD204 / MSR1 ELISA Kit
Human CD204 / MSR1 ELISA Kit for ELISA and Human
Overview
| Product Description | ARG83333 Human CD204 / MSR1 ELISA Kit is a high sensitive Enzyme Immunoassay kit for the quantification of Human CD204 / MSR1 in Serum, Plasma, Cell culture supernatants. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | There is no detectable cross-reactivity with other relevant proteins. |
| Target Name | CD204 / MSR1 |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm |
| Sensitivity | 45 pg/ml |
| Detection Range | 93.7 - 6000 pg/ml |
| Sample Type | Serum, Plasma, Cell culture supernatants |
| Precision | CV: less than10% |
| Alternate Names | MSR1; Macrophage Scavenger Receptor 1; SCARA1; SR-AIII; SR-AII; CD204; SR-AI; SR-A; Macrophage Scavenger Receptor Types I And II; Macrophage Acetylated LDL Receptor I And II; Scavenger Receptor Class A Member 1; Macrophage Scavenger Receptor Type III; CD204 Antigen; PhSR1; PhSR2; SRA |
Application Instructions
| Assay Time | 4.5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P21757 Human Macrophage scavenger receptor types I and II |
|---|---|
| Gene Symbol | MSR1 |
| Gene Full Name | Macrophage Scavenger Receptor 1 |
| Background | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. |
| Function | Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). |
| Cellular Localization | LDL, Membrane |
| PTM | Disulfide bond, Glycoprotein, Phosphoprotein |
| Title | Download Link |
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| ARG83333 Human CD204 / MSR1 ELISA Kit User manual |
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