ARG81330

Human CD253 / TRAIL ELISA Kit

Human CD253 / TRAIL ELISA Kit for ELISA and Human

Overview

Product Description ARG81330 Human CD253 / TRAIL ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human CD253 / TRAIL in serum, plasma and cell culture supernatant.
Tested Reactivity Hu
Tested Application ELISA
Specificity Recognizes both natural and recombinant soluble Human TRAIL. No cross reactivity with other Human soluble molecules.
Target Name CD253 / TRAIL
Conjugation HRP
Conjugation Note Substrate: TMB and read at 450 nm.
Sensitivity 64 pg/ml
Sample Type Serum, plasma and cell culture supernatants.
Standard Range 93.75 - 3000 pg/ml
Sample Volume 100 µl
Alternate Names TL2; CD253; Protein TRAIL; TNF-related apoptosis-inducing ligand; TRAIL; CD antigen CD253; Apo-2 ligand; Apo-2L; APO2L; Tumor necrosis factor ligand superfamily member 10

Application Instructions

Assay Time ~ 4 hours

Properties

Form 96 well
Storage Instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 8743 Human TNFSF10

Swiss-port # P50591 Human Tumor necrosis factor ligand superfamily member 10

Gene Symbol TNFSF10
Gene Full Name tumor necrosis factor (ligand) superfamily, member 10
Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Function Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [UniProt]
Highlight Related products:
CD253 antibodies; CD253 ELISA Kits;
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PTM Tyrosine phosphorylated by PKDCC/VLK. [UniProt]
Title Download Link
ARG81330 Human CD253 / TRAIL ELISA Kit User's manual download icon Download