ARG70264

Human CD266 / TWEAK R recombinant protein (Active) (ECD) (Fc-His-tagged, C-ter)

Human CD266 / TWEAK R recombinant protein (Active) (ECD) (Fc-His-tagged, C-ter) for SDS-PAGE,Functional study and Human

Overview

Product Description HEK293 expressed, Fc-His-tagged (C-ter) Active Human CD266 / TWEAK R recombinant protein (ECD).
Tested Reactivity Hu
Tested Application FuncSt, SDS-PAGE
Target Name CD266 / TWEAK R (ECD)
Species Human
A.A. Sequence Glu28 - Trp79 of Human CD266 / TWEAK R (NP_057723.1) with an Fc-6X His tag at the C-terminus.
Expression System HEK293
Activity Active
Activity Note Measured by its ability to inhibit TWEAK-induced apoptosis in HT-29 human colon adenocarcinoma cells. The ED50 for this effect is 2-12 µg/ml in the presence of 1 µg/ml recombinant human TWEAK.
Alternate Names Tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; CD266; Fibroblast growth factor-inducible immediate-early response protein 14; TWEAKR; TweakR; CD antigen CD266; Tweak-receptor; FN14

Properties

Form Powder
Purification Note 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test.
Purity > 90% (by SDS-PAGE)
Buffer PBS (pH 7.4)
Reconstitution Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water.
Storage Instruction Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 51330 Human TNFRSF12A

Swiss-port # Q9NP84 Human Tumor necrosis factor receptor superfamily member 12A

Gene Symbol TNFRSF12A
Gene Full Name tumor necrosis factor receptor superfamily, member 12A
Function Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 14 kDa