ARG82201
Human Cardiac Troponin I (High sensitive) ELISA Kit
Human Cardiac Troponin I (High sensitive) ELISA Kit for ELISA and Human
Overview
| Product Description | ARG82201 Human Cardiac Troponin I (High sensitive) ELISA Kit is a high sensitive Enzyme Immunoassay kit for the quantification of Human Cardiac Troponin I in serum, plasma and cell culture supernatants. |
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| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | Not react with the following recombinant human proteins: Adiponectin, ApoAI, BMP1, BMP2, BMP3, BMP4, BMP5, BMP7, CCL2, CCL4, CCL5, CRP, HGF, HSP27, IL1 beta, IL1RA, IL1 alpha, IL1RI, IL2, IL4, IL5, IL6, IL6R, IL8, IL12, IL13, IL15, IL17C, IL21, IL23, IFN beta, IFN gamma, PDGF, PLA2G7, prolactin, serpin E1, TGF beta 1, TGF beta 2, TGF beta 3, TLR1, TLR2, TL3, TLR9, TNF alpha, TNF RI, TNF RII, VEGF, VEGF R1. |
| Target Name | Cardiac Troponin I |
| Conjugation | HRP |
| Conjugation Note | Read at 450 nm. |
| Sensitivity | 18 pg/ml |
| Sample Type | Serum, plasma and cell culture supernatants. |
| Standard Range | 93.75 - 6000 pg/ml |
| Sample Volume | 100 µl |
| Precision | Intra-Assay CV: 5% Inter-Assay CV: 8% |
| Alternate Names | RCM1; cTnI; Cardiac troponin I; TNNC1; CMD1FF; CMD2A; Troponin I, cardiac muscle; CMH7 |
Application Instructions
| Assay Time | 3 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
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| Gene Symbol | TNNI3 |
| Gene Full Name | troponin I type 3 (cardiac) |
| Background | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008] |
| Function | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. [UniProt] |
| Highlight | Related products: Troponin antibodies; Troponin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| PTM | Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity). Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). [UniProt] |
| Title | Download Link |
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| ARG82201 Human Cardiac Troponin I (High sensitive) ELISA Kit User manual |
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