ARG83271
Human Desmocollin 2 ELISA Kit
Human Desmocollin 2 ELISA Kit for ELISA and Human
Overview
| Product Description | ARG83271 Human Desmocollin 2 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Desmocollin 2 in Serum, Plasma and Cell culture supernatants. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | There is no detectable cross-reactivity with other relevant proteins. |
| Target Name | Desmocollin 2 |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 13 pg/ml |
| Detection Range | 156 pg/ml - 10,000 pg/ml |
| Sample Type | Serum, Plasma and Cell culture supernatants |
| Precision | Intra-Assay CV: 6.6% Inter-Assay CV: 6.3% |
| Alternate Names | Desmosomal glycoprotein II; ARVD11; Desmosomal glycoprotein III; DSC3; Desmocollin-3; Desmocollin-2; DG2; CDHF2; DGII/III; Cadherin family member 2 |
Application Instructions
| Assay Time | ~ 5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | DSC2 |
| Gene Full Name | desmocollin 2 |
| Background | This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. [UniProt] |
| Cellular Localization | Cell membrane, Single-pass type I membrane protein, Cell junction, desmosome. [UniProt] |
| Title | Download Link |
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| ARG83271 Human Desmocollin 2 ELISA Kit User manual |
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