ARG81139
Human Endostatin ELISA Kit
Human Endostatin ELISA Kit for ELISA and Human
Overview
| Product Description | ARG81139 Human Endostatin ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Endostatin in serum and plasma. |
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| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | The following recombinant human proteins prepared at 1 ng/ml were tested and exhibited no cross-reactivity or interference: Adiponectin, ApoAI, BMP1, BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, CCL2, CCL4, CCL5, CRP, FGF acidic, HGF, HSP27, IGF-1, IL-1α, IL-1β, IL-1ra, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17C, ENDOSTATIN1, ENDOSTATIN3, IFN-α, IFN-β, IFN, MMP-2, MMP-3, MMP-9, PDGF, PLA2G7, prolactin, TLR1, TLR2, TLR3, TLR4, TLR9, TGF-β1, TGF-β2, TGF-β3, TNF-α, TNF RI, TNF RII, VEGF, VEGF-R1 |
| Target Name | Endostatin |
| Conjugation Note | Read at 450 nm. Please refer the user manual for the detail. |
| Sensitivity | 12 pg/ml |
| Sample Type | Serum and plasma. |
| Standard Range | 62.5 - 4000 pg/ml |
| Sample Volume | 100 µl |
| Alternate Names | KS; KNO; KNO1; Collagen alpha-1(XVIII) chain |
Application Instructions
| Assay Time | ~ 3 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
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| Gene Symbol | COL18A1 |
| Gene Full Name | collagen, type XVIII, alpha 1 |
| Background | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| Function | COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. [UniProt] |
| Highlight | Related products: Endostatin antibodies; Endostatin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| PTM | Prolines at the third position of the tripeptide repeating unit (G-X-Y) of the triple-helical regions are hydroxylated. |
| Title | Download Link |
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| ARG81139 Human Endostatin ELISA Kit User manual |
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