ARG80494

Human IGFBP3 ELISA Kit

Human IGFBP3 ELISA Kit for ELISA and Human

Cell Biology and Cellular Response kit; Cell Death kit; Metabolism kit; Signaling Transduction kit

Overview

Product Description ARG80494 Human IGFBP3 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human IGFBP3 in serum and plasma (EDTA, heparin).
Tested Reactivity Hu
Tested Application ELISA
Target Name IGFBP3
Sensitivity 0.1 ng/ml
Sample Type Serum and plasma (EDTA, heparin).
Standard Range 0.4 - 30 ng/ml
Sample Volume 10 µl
Alternate Names IBP-3; IBP3; Insulin-like growth factor-binding protein 3; IGFBP-3; IGF-binding protein 3; BP-53

Application Instructions

Assay Time 1 h, 1 h, 30 min (RT/shaker)

Properties

Form 96 well
Storage Instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Symbol IGFBP3
Gene Full Name insulin-like growth factor binding protein 3
Background This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. [UniProt]
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Research Area Cell Biology and Cellular Response kit; Cell Death kit; Metabolism kit; Signaling Transduction kit
PTM Phosphorylated by FAM20C in the extracellular medium.
Title Download Link
ARG80494 Human IGFBP3 ELISA Kit User's manual download icon Download