ARG70324

Human LTBR / Lymphotoxin beta Receptor recombinant protein (ECD) (Fc-His-tagged, C-ter)

Human LTBR / Lymphotoxin beta Receptor recombinant protein (ECD) (Fc-His-tagged, C-ter) for SDS-PAGE,Binding Activity and Human

Overview

Product Description HEK293 expressed, Fc-His-tagged (C-ter) Human LTBR / Lymphotoxin beta Receptor recombinant protein (ECD).
Tested Reactivity Hu
Tested Application Binding, SDS-PAGE
Target Name LTBR / Lymphotoxin beta Receptor (ECD)
Species Human
A.A. Sequence Gln31 - Met227 of Human LTBR / Lymphotoxin beta Receptor (NP_002333.1) with an Fc-6X His tag at the C-terminus.
Expression System HEK293
Alternate Names TNF-RIII; LT-BETA-R; Tumor necrosis factor receptor superfamily member 3; TNF-R-III; TNFR-III; TNFR-RP; TNFR3; D12S370; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; TNFCR; Tumor necrosis factor receptor type III; Lymphotoxin-beta receptor; TNFR2-RP; CD18; TNFRSF3

Application Instructions

Application Note Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human LIGHT at 1µg/ml (100 µl/well) can bind Recombinant Human LTBR with a linear range of 14.3-57.4 ng/ml.

Properties

Form Powder
Purification Note 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test.
Purity > 95% (by SDS-PAGE)
Buffer PBS (pH 7.4)
Reconstitution Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water.
Storage Instruction Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 4055 Human LTBR

Swiss-port # P36941 Human Tumor necrosis factor receptor superfamily member 3

Gene Symbol LTBR
Gene Full Name lymphotoxin beta receptor (TNFR superfamily, member 3)
Background This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
Function Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 47 kDa