ARG82971

Human Lymphotoxin Alpha / TNF beta ELISA Kit

Human Lymphotoxin Alpha / TNF beta ELISA Kit for ELISA and Human

Overview

Product Description ARG82971 Human Lymphotoxin Alpha / TNF beta ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Lymphotoxin Alpha / TNF beta in serum, plasma, cell culture supernatant samples.
Tested Reactivity Hu
Tested Application ELISA
Specificity Cross-Reactivity: Not reacts with Human GM-CSF, IL8, IL1 beta, TNF alpha and Mouse TNF alpha.
Target Name Lymphotoxin alpha / TNF beta
Conjugation HRP
Conjugation Note Substrate: TMB and read at 450 nm.
Sensitivity 7.8 pg/ml
Sample Type Serum, plasma and cell culture supernatants.
Standard Range 15.6 - 1000 pg/ml
Sample Volume 100 µl
Precision Intra-Assay CV: < 10%
Inter-Assay CV: < 10%
Alternate Names Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT; Lymphotoxin-alpha; TNFB; TNFSF1; LT-alpha

Application Instructions

Assay Time ~ 4 hours

Properties

Form 96 well
Storage Instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 4049 Human LTA

Swiss-port # P01374 Human Lymphotoxin-alpha

Gene Symbol LTA
Gene Full Name lymphotoxin alpha
Background The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Function Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. [UniProt]
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