ARG70279
Human MMP3 recombinant protein (His-tagged, C-ter)
Human MMP3 recombinant protein (His-tagged, C-ter) for SDS-PAGE and Human
Overview
| Product Description | HEK293 expressed, His-tagged (C-ter) Human MMP3 recombinant protein. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | SDS-PAGE |
| Target Name | MMP3 |
| Species | Human |
| A.A. Sequence | Tyr18 - Cys477 of Human MMP3 (NP_002413.1) with 6X His tag at the C-terminus. |
| Expression System | HEK293 |
| Alternate Names | Transin-1; CHDS6; EC 3.4.24.17; SL-1; STMY1; Matrix metalloproteinase-3; STR1; STMY; MMP-3; Stromelysin-1 |
Properties
| Form | Powder |
|---|---|
| Purification Note | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | > 90% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| Storage Instruction | Lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MMP3 |
| Gene Full Name | matrix metallopeptidase 3 |
| Background | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] |
| Function | Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. [UniProt] |
| Cellular Localization | Secreted, extracellular space, extracellular matrix. [UniProt] |
| Calculated MW | 54 kDa |
