ARG83341
Human PILRA ELISA Kit
Human PILRA ELISA Kit for ELISA and Human
Overview
| Product Description | ARG83341 Human PILRA ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human PILRA in serum, plasma and cell culture supernatants. |
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| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | There is no detectable cross-reactivity with other relevant proteins. |
| Target Name | PILRA |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 75 pg/ml |
| Detection Range | 156 pg/ml - 10000 pg/ml |
| Sample Type | Serum, Plasma and Cell culture supernatants. |
| Alternate Names | PILRA; Paired Immunoglobin Like Type 2 Receptor Alpha; FDF03; Paired Immunoglobulin-Like Type 2 Receptor Alpha; Inhibitory Receptor PILR-Alpha; Cell Surface Receptor FDF03; Paired Immunoglobin-Like Type 2 Receptor Alpha |
Application Instructions
| Assay Time | ~ 5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9UKJ1 Human Paired immunoglobulin-like type 2 receptor alpha |
|---|---|
| Gene Symbol | PILRA |
| Gene Full Name | Paired Immunoglobin Like Type 2 Receptor Alpha |
| Background | Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. |
| Function | Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. |
| Cellular Localization | Cell membrane, Membrane, Secreted |
| PTM | Glycoprotein, Phosphoprotein |
| Title | Download Link |
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| ARG83341 Human PILRA ELISA Kit User manual |
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