ARG81269

Human Pro-Collagen I alpha 1 ELISA Kit

Human Pro-Collagen I alpha 1 ELISA Kit for ELISA and Human

Overview

Product Description

ARG81269 Human Pro-Collagen I alpha 1 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Pro-Collagen I alpha 1 in serum, plasma or cell culture supernatants.

Tested Reactivity Hu
Tested Application ELISA
Target Name Collagen I
Conjugation HRP
Conjugation Note

Substrate: TMB and read at 450 nm.

Sensitivity 15 pg/ml
Sample Type Serum, plasma or cell culture supernatants.
Standard Range 31.25 - 2000 pg/ml
Sample Volume 100 µl
Alternate Names OI1; OI2; OI3; OI4; EDSC; Collagen alpha-1(I) chain; Alpha-1 type I collagen

Application Instructions

Assay Time ~ 3.5 hours

Properties

Form 96 well
Storage Instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 1277 Human COL1A1

Swiss-port # P02452 Human Collagen alpha-1(I) chain

Gene Symbol COL1A1
Gene Full Name collagen, type I, alpha 1
Background This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Function Type I collagen is a member of group I collagen (fibrillar forming collagen). [UniProt]
Highlight Related products:
Collagen I antibodies; Collagen I ELISA Kits; Collagen I Duos / Panels;
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New ELISA data calculation tool:
Simplify the ELISA analysis by GainData
PTM Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Title Download Link
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