ARG81272

Human TIMP-2 ELISA Kit

Human TIMP-2 ELISA Kit for ELISA and Human

Overview

Product Description ARG81272 Human TIMP-2 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human TIMP-2 in serum, plasma or cell culture supernatants.
Tested Reactivity Hu
Tested Application ELISA
Target Name TIMP2
Conjugation HRP
Conjugation Note Substrate: TMB and read at 450 nm.
Sensitivity 15 pg/ml
Sample Type Serum, plasma or cell culture supernatants.
Standard Range 31.25 - 2000 pg/ml
Sample Volume 100 µl
Alternate Names TIMP-2; Tissue inhibitor of metalloproteinases 2; CSC-21K; DDC8; Metalloproteinase inhibitor 2

Application Instructions

Assay Time ~ 3.5 hours

Properties

Form 96 well
Storage Instruction Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 7077 Human TIMP2

Swiss-port # P16035 Human Metalloproteinase inhibitor 2

Gene Symbol TIMP2
Gene Full Name TIMP metallopeptidase inhibitor 2
Background This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. [UniProt]
Highlight Related products:
TIMP2 antibodies; TIMP2 ELISA Kits;
Related news:
Detecting MMPs and their non-ECM substrates
New ELISA data calculation tool:
Simplify the ELISA analysis by GainData
PTM The activity of TIMP2 is dependent on the presence of disulfide bonds.
Title Download Link
ARG81272 Human TIMP-2 ELISA Kit User's manual download icon Download