ARG80892
Human TPO / Thyroid Peroxidase autoantibodies ELISA Kit
Human TPO / Thyroid Peroxidase autoantibodies ELISA Kit for ELISA and Human
Immune System kit
Overview
| Product Description | ARG80892 Human TPO / Thyroid Peroxidase autoantibodies ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Thyroid Peroxidase autoantibodies in serum and plasma (EDTA, heparin, citrate) (1:100 diluted). |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Target Name | TPO / Thyroid Peroxidase autoantibody |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm |
| Sensitivity | 5 IU/ml |
| Sample Type | Serum and plasma (EDTA, heparin, citrate) (1:100 diluted). |
| Standard Range | 33 - 3,000 IU/ml |
| Sample Volume | 10 µl |
Application Instructions
| Assay Time | 30, 15, 15, 5 min (RT) |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Thyreoidal Peroxidase Autoantibodies (TPO-Ab) |
|---|---|
| Background | Thyroid disorders are the most prevalent of all autoimmune diseases. Thyroid autoimmune diseases are associated with the occurrence of differentiated autoantibodies and are thought to be related to a genetical pre-disposition. These autoantibodies are directed against membrane- located and/or extracellular antigens of the thyroid cells: Human Thyroglobulin (hTG), a water soluble glycoprotein with a molecular weight of approx. 660.000 Dalton, is the principal constituent of the thyroidal colloid sharing about 75 % of its mass. Synthesis of the thyroid hormones T3 and T4 is based on the oxidative iodination of tyrosine residues of the thyroglobulin molecule. Within the cell thyroglobulin is transported by the microsomes. Together with the secretion of T3 and T4 also small amounts of hTG are liberated into circulation. The microsomal antigen of the thyroid is an integral membrane protein of the microsomes. It has been characterised as the enzyme Thyroid Peroxidase (TPO) with a molecular weight of nearly 110.000 Dalton. The TSH-Receptor is a regulatory protein embedded into the thyroid cell membrane effecting synthesis and release of the thyroid hormones as well as cellular growth. The so-called Colloid-Antigen 2 CA2. |
| Highlight | Related products: Thyroid Peroxidase antibodies; Thyroid Peroxidase ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| Research Area | Immune System kit |
| Title | Download Link |
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| ARG80892 Human Thyroid Peroxidase (TPO) autoantibodies ELISA Kit User's manual |
 Download
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