ARG81318
Human Thrombomodulin ELISA Kit
Human Thrombomodulin ELISA Kit for ELISA and Human
Overview
| Product Description | ARG81318 Human Thrombomodulin ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Thrombomodulin in serum, plasma and cell culture supernatant. |
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| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Specificity | Recognizes both natural and recombinant Human soluble Thrombomodulin. No cross reactivity with other Human soluble molecules. |
| Target Name | Thrombomodulin |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 0.31 ng/ml |
| Sample Type | Serum, plasma and cell culture supernatants. |
| Standard Range | 0.625 - 20 ng/ml |
| Sample Volume | 100 µl (cell culture supernatants); 50 µl (serum and plasma) |
| Alternate Names | THRM; CD antigen CD141; THPH12; TM; Thrombomodulin; CD141; BDCA3; Fetomodulin; AHUS6 |
Application Instructions
| Assay Time | ~ 2 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | THBD |
| Gene Full Name | thrombomodulin |
| Background | The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] |
| Function | Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. [UniProt] |
| Highlight | Related products: Thrombomodulin antibodies; Thrombomodulin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| PTM | N-glycosylated. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. [UniProt] |
| Title | Download Link |
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| ARG81318 Human Thrombomodulin ELISA Kit User's manual |
 Download
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