ARG30234
IFN gamma ELISA Antibody Duo
Cancer antibody; Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG65520 | anti-IFN gamma antibody [NIB42] | Mouse mAb | Hu | ELISA, FuncSt, IP, RIA | 100 μg |
| ARG65396 | anti-IFN gamma antibody [4S.B3] (Biotin) | Mouse mAb | Hu, NHuPrm | ELISA, FACS, ICC/IF, IHC-P, WB | 50 μg |
Overview
| Product Description | IFN-gamma, also called Type II interferon, is a homodimeric glycoprotein containing approximately 21 to 24 kD subunits. The human IFN-gamma gene, situated on chromosome 12, contains three introns; the four exons code for a polypeptide of 166 amino acids, 20 of which constitute the signal peptide. In contrast to IFN-a and IFN-b synthesis, which can occur in any cell, production of IFN-gamma is a function of T cells and NK cells. All IFN-gamma inducers activate T cells either in a polyclonal (mitogens or antibodies) or in a clonally restricted, antigen-specific, manner. IFN-gamma is produced during infection by T cells of the cytotoxic/ suppressor phenotype CD8 and by a subtype of helper T cells, the Th1 cells. Th1 cells secrete IL-2, IL-3, TNF-beta and IFN-gamma, whereas Th2 cells mainly produce IL-3, IL-4, IL-5, and IL-10, but little or no IFN-gamma. IFN-g preferentially inhibits the proliferation of Th2 but not Th1 cells, indicating that the presence of IFN-gamma during an immune response will result in the preferential proliferation of Th1 cells. Recommend using Capture antibody: ARG65520, suggested dilution: 2-6 ug/ml Detection antibody: ARG65396, suggested dilution: 0.5-2 ug/ml Related news: HMGB1 in inflammation Inflammatory Cytokines |
|---|---|
| Target Name | IFN gamma |
| Alternate Names | IFN gamma ELISA antibody; Biotin-conjugated IFN gamma antibody; IFN gamma antibody |
Properties
| Storage Instruction | Store antibodies at 4°C or -20°C. Please refer to the each product datasheet for detail temperatures of the antibodies. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | ELISA Antibody Duo for IFN gamma |
|---|---|
| Background | This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia. [provided by RefSeq, Nov 2009] |
| Function | Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. [provided by Uniprot] |
| Highlight | Related products: IFN gamma antibodies; IFN gamma ELISA Kits; IFN gamma Duos / Panels; IFN gamma recombinant proteins; |
| Research Area | Cancer antibody; Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody |
| PTM | Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161. |
