ARG82053
Mouse Gremlin ELISA Kit
Mouse Gremlin ELISA Kit for ELISA and Mouse
Overview
| Product Description | Mouse Gremlin ELISA Kit is an Enzyme Immunoassay kit for the quantification of Mouse Gremlin in serum, plasma and cell culture supernatants. |
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| Tested Reactivity | Ms |
| Tested Application | ELISA |
| Target Name | Gremlin |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 46.9 pg/ml |
| Sample Type | Serum, plasma and cell culture supernatants. |
| Standard Range | 93.8 - 6000 pg/ml |
| Sample Volume | 100 µl |
| Alternate Names | GREMLIN; Increased in high glucose protein 2; Gremlin-1; DUP15q; DAND2; CRAC1; MPSH; CKTSF1B1; PIG2; DRM; HMPS1; DAN domain family member 2; IHG-2; HMPS; Cysteine knot superfamily 1, BMP antagonist 1; Cell proliferation-inducing gene 2 protein; C15DUPq; CRCS4; Down-regulated in Mos-transformed cells protein |
Application Instructions
| Assay Time | 4.5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GREM1 |
| Gene Full Name | gremlin 1, DAN family BMP antagonist |
| Background | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
| Function | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis (By similarity). [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Highlight | Related products: Gremlin antibodies; Gremlin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| Title | Download Link |
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| ARG82053 Mouse Gremlin ELISA Kit User manual |
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