ARG30233
Phospho Bcl XL Antibody Duo (Total, pS62)
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51569 | anti-Bcl XL phospho (Ser62) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG51057 | anti-Bcl XL antibody | Rabbit pAb | Hu, Ms, Rat | WB | 50 μl |
Overview
| Product Description | Members of the Bcl family of proteins are important regulators of programmed cell death pathways with individual members that can suppress (eg Bcl2, Bcl-XL) or promote (eg Bax, Bad) apoptosis. BCL-XL is a transmembrane molecule in the mitochondria, acts as a pro-survival protein by preventing the release of mitochondrial contents such as Cytochrome C which would lead to caspase activation. Ser62 residue of BCL-XL protein was found to be the major site of BCL-XL protein phosphorylation. This phosphorylation induced by microtubule inhibitors plays a key pro-apoptotic role in part by disabling the ability of Bcl-xL to bind Bax. Upreti et al. 2008. J Biol Chem 283(51): 35517 |
|---|---|
| Target Name | Bcl XL |
| Alternate Names | Phospho Bcl XL antibody; Bcl XL antibody; Bcl XL phospho (Ser62) antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho Bcl XL Antibody Duo (Total, pS62) |
|---|---|
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody |
