ARG30037
Phospho IKB alpha Antibody Duo (Total, pS32/36)
Cancer antibody; Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody
Publication2
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51651 | anti-IKB alpha phospho (Ser32 / Ser36) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG54059 | anti-IkB alpha antibody (N-term) | Mouse mAb | Hu, Ms, Rat | WB | 50 μl |
Overview
| Product Description | IκB-α inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, triggers IκB-α phosphorylated at Ser32/36 and promotes IκB-α ubiquitination and degradation, enabling the dimeric NFkB to translocate to the nucleus and activate transcription. ARG30037 IκB-α phospho Duos (Total, pS32/36), includes an antibody reacts total IκB-α protein and an antibody recognizes IκB-α only when Ser32/36 of IκB-α is phosphorylated. This antibody Duos could be used in evaluation of total or Ser32/36 phosphorylated IκB-α protein in IκB-α/NFkB signaling and IκB-α/NFkB regulation studies. |
|---|---|
| Target Name | IKB alpha |
| Alternate Names | Phospho IKB alpha antibody; Phospho nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha antibody; IKB alpha phospho (Ser32 / Ser36) antibody; IkB alpha antibody (N-term) |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IKB alpha) Antibody Duo (Total, pS32/36) |
|---|---|
| Research Area | Cancer antibody; Gene Regulation antibody; Immune System antibody; Signaling Transduction antibody |
Specific References
Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury
ARG51651, ARG54059: WB / Human
Effects and mechanisms of PSS-loaded nanoparticles on coronary microcirculation dysfunction in streptozotocin-induced diabetic cardiomyopathy rats.
ARG51651, ARG54059: WB / Rat
