ARG30353
Phospho IKB alpha Antibody Duo (Total, pS32 / 36)
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51651 | anti-IKB alpha phospho (Ser32 / Ser36) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG40630 | anti-IKB alpha antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, IP, WB | 50 μl |
Overview
| Product Description | IκB-α inhibits the activity of dimeric NF-kappa-B / REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, triggers IκB-α phosphorylated at Ser32 / 36 and promotes IκB-α ubiquitination and degradation, enabling the dimeric NFkB to translocate to the nucleus and activate transcription. ARG30053 IκB-α phospho Duos (Total, pS32 / 36), includes an antibody reacts total IκB-α protein and an antibody recognizes IκB-α only when Ser32 / 36 of IκB-α is phosphorylated. This antibody Duos could be used in evaluation of total or Ser32 / 36 phosphorylated IκB-α protein in IκB-α / NFkB signaling and IκB-α / NFkB regulation studies. |
|---|---|
| Target Name | Phospho IKB alpha |
| Alternate Names | Phospho nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IKB alpha) Antibody Duo (Total, pS32/36) |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Background | |Phospho IKB alpha Antibody Duo Total, pS32/36|anti IkB alpha antibody2E10 B11 F6, N terminal|2E10 B11 F6|NF kappa B inhibitor alpha|I kappa B alpha|IkB alpha|IkappaBalpha|Major histocompatibility complex enhancer binding protein MAD3|2E10 B11 F6|IKB alpha|IKB alpha|anti IKB alpha phospho Ser32/Ser36 antibody|NFKBIA|nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha|IKBA|MAD3|NFKBI|NF kappa B inhibitor alpha|I kappa B alpha|IkB alpha|IkappaBalpha|Major histocompatibility complex enhancer binding protein MAD3|IKBA|MAD3|NFKBI|IKB alpha|IKB alpha| |
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