ARG30254
Phospho NFkB p65 Antibody Duo (Total, pT435)
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Immune System antibody; Metabolism antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody; Signaling Transduction antibody
Publication8
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51516 | anti-NFkB p65 phospho (Thr435) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG65677 | anti-NFkB p65 antibody | Mouse mAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μg |
Overview
| Product Description | Nuclear factor kappa B (NF-κB) is a protein complex that controls large number of genes responsible for the regulation of apoptosis, inflammation, tumorigenesis and a variety of immune responses. NF-kB is sensitive and responsive to stimuli such as cytokines, stress, UV, low oxygen, bacterial or viral infections. In most cell types, NF-κB subunits exist as hetero- or homodimers bound to the inhibitory IκB proteins, which retain the complex mainly in the cytoplasm. Once activated, IκB proteins are phosphorylated by IKKα and IKKβ, leading to the degradation of IκB proteins and nuclear translocation of NF-κB proteins. Post-translation modification such as phosphorylation of NF-κB p65 at Thr435 site leads to transcription activity and NF-κB subunit transactivation. O’Shea and Perkins. Biochem J. 2010. 426: 345-354 Hayden and Ghosh. (2012) Genes and Dev 26: 203-234 Baeuerle and Henkel. (1994) Ann Rev Immunol 12: 141-179 Related news: Exploring Antiviral Immune Response |
|---|---|
| Target Name | NFkB p65 |
| Alternate Names | Phospho NFkB p65 antibody; NFkB p65 phospho (Thr435) antibody; NFkB p65 antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho NFkB p65 Antibody Duo (Total, pT435) |
|---|---|
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Immune System antibody; Metabolism antibody; Microbiology and Infectious Disease antibody; Neuroscience antibody; Signaling Transduction antibody |
Specific References
Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury
ARG65677: WB / Human
Hyperhomocysteinemia Promotes Cardiac Hypertrophy in Hypertension
ARG65677: WB / Mouse
Neohesperidin Protects Angiotensin II-Induced Hypertension and Vascular Remodeling.
ARG65677: WB / Mouse
Thalidomide Alleviates Pulmonary Fibrosis Induced by Silica in Mice by Inhibiting ER Stress and the TLR4-NF-κB Pathway
ARG51516: WB / Mouse
OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis
ARG51516: WB / Rat
Inhibition of inflammatory response by α-lipoic acid in autoimmune thyroiditis mice.
ARG65677: WB / Mouse
The fucoidan from sea cucumber Apostichopus japonicus attenuates lipopolysaccharide-challenged liver injury in C57BL/6J mice.
WB / Mouse
Activation of GABAB Receptor Suppresses Diabetic Neuropathic Pain through Toll-Like Receptor 4 Signaling Pathway in the Spinal Dorsal Horn.
ARG65677: WB, ICC/IF / Rat
