ARG30014
Phospho PKM2 Antibody Duo (Total, pS37)
Cancer antibody; Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG61996 | anti-PKM1/2 antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG51804 | anti-PKM2 phospho (Ser37) antibody | Rabbit pAb | Hu | WB, ICC/IF | 50 μl |
Overview
| Product Description | In 2012, Yang et al. reported that PKM2, but not PKM1, can be phosphorylated at Ser37 by ERK2 through the activation of EGF Receptor. The phosphorylated PKM2 translocates to nucleus and act as a coactivator of beta catenin to induce c-myc expression and results in PKM2-dependant GLUT1, LDHA and PTB upregulation. In conclusion, the level of PKM2 Ser37 phosphorylation might play an important role in Warburg effect and tumorigenesis.[PMID:23178880] ARG30014 PKM2 phospho Duos provides antibodies react non-phosphorylated or phosphorylated PKM2 at Ser37, can be used as an antibody pair in PKM2 study |
|---|---|
| Target Name | PKM2 |
| Alternate Names | Phospho PKM2 antibody; PKM2 phospho (Ser37) antibody; PKM1/2 antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Antibody Duo for Phospho PKM2 (Total, pS37) |
|---|---|
| Research Area | Cancer antibody; Gene Regulation antibody; Metabolism antibody; Signaling Transduction antibody |
