ARG30043
Phospho ZAP70 Antibody Duo (pY319, pY493)
Controls and Markers antibody; Immune System antibody; Signaling Transduction antibody
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51657 | anti-ZAP70 phospho (Tyr319) antibody | Rabbit pAb | Hu, Ms, Rat | WB, ICC/IF | 50 μl |
| ARG51658 | anti-ZAP70 phospho (Tyr493) antibody | Rabbit pAb | Hu, Ms, Rat | WB, IHC-P | 50 μl |
Overview
| Product Description | ZAP70, Zeta-chain-associated protein kinase 70 (70kDa), is a tyrosine kinase protein normally expressed near the surface membrane of T cells and natural killer cells and plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Phosphorylation of Tyr-315 and Tyr-319 are essential for ZAP70 positive function on T-lymphocyte activation whereas Tyr-292 has a negative regulatory role. Within the C-terminal kinase domain, Tyr-492 and Tyr-493 are phosphorylated after TCR induction, Tyr-492 playing a negative regulatory role and Tyr-493 a positive. Tyr-493 is dephosphorylated by PTN22. ARG30043 ZAP70 phospho Duos (pY319, pY493), includeing antibodies react two important phosphorylation site of ZAP70 on Tyr-319 and Tyr-493, is useful for ZAP70 signaling transduction studies. |
|---|---|
| Target Name | ZAP70 |
| Alternate Names | Phospho ZAP70 antibody; Phospho Zeta chain of T cell receptor associated protein kinase 70 antibody; ZAP70 phospho (Tyr319) antibody; ZAP70 phospho (Tyr493) antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho Zeta chain of T cell receptor associated protein kinase 70 (ZAP70) Antibody Duo (pY319, pY493) |
|---|---|
| Research Area | Controls and Markers antibody; Immune System antibody; Signaling Transduction antibody |
