ARG83380
Pyrimidine Dimer ELISA Kit
Pyrimidine Dimer ELISA Kit for ELISA and Other
DNA, MutationDimers (chemistry), DNA replication and repair-deficiency disorders, Senescence, Cyclobutanes
Overview
| Product Description | ARG83380 Pyrimidine Dimers ELISA Kit is an Enzyme Immunoassay kit for the quantification of Pyrimidine Dimer in Cell / Tissue genomic DNA |
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| Tested Reactivity | Other |
| Tested Application | ELISA |
| Target Name | Pyrimidine Dimer |
| Conjugation | HRP |
| Conjugation Note | Read at 450 nm. |
| Sensitivity | 0.8 ng/mL |
| Sample Type | Cell / Tissue genomic DNA |
| Standard Range | 1.56 - 100 ng/mL |
| Sample Volume | 50 µL |
Application Instructions
| Assay Time | ~3.5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store components at 4°C, -20°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Background | Absorption of ultraviolet (UV) light produces two predominant types of DNA damage, cyclobutane pyrimidine dimers and pyrimidine pyrimidone photoproducts. The result is a transition of C to T and CC to TT, which are the most frequent mutations of p53 in both human and mouse skin cancers. UV damaged DNA is usually repaired by nucleotide excision repair or base excision repair. After UV exposure, cells activate p53 and stall the cell cycle for repair. If the damage is too severe, the cell will trigger apoptosis to get rid of DNA damaged, potentially mutant cells. |
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| Research Area | DNA, MutationDimers (chemistry), DNA replication and repair-deficiency disorders, Senescence, Cyclobutanes |
| Title | Download Link |
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| ARG83380 Pyrimidine Dimer ELISA Kit User manual |
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