ARG57092

anti-14-3-3 tau / YWHAQ antibody [1A1]

anti-14-3-3 tau / YWHAQ antibody [1A1] for ICC/IF,Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [1A1] recognizes 14-3-3 tau / YWHAQ
Tested Reactivity Hu
Tested Application ICC/IF, WB
Host Mouse
Clonality Monoclonal
Clone 1A1
Isotype IgG1, kappa
Target Name 14-3-3 tau / YWHAQ
Antigen Species Human
Immunogen Recombinant fragment around aa. 1-245 of Human 14-3-3 tau / YWHAQ
Conjugation Un-conjugated
Alternate Names 14-3-3; Protein HS1; 1C5; HS1; 14-3-3 protein theta; 14-3-3 protein tau; 14-3-3 protein T-cell

Application Instructions

Application Suggestion
Tested Application Dilution
ICC/IFAssay-dependent
WB1:1000 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein G.
Buffer PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 10% Glycerol
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 10971 Human YWHAQ

Swiss-port # P27348 Human 14-3-3 protein theta

Gene Symbol YWHAQ
Gene Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
Background This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. [UniProt]
Calculated MW 28 kDa
PTM Ser-232 is probably phosphorylated by CK1.