ARG58811
anti-17 beta HSD 4 antibody
anti-17 beta HSD 4 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes 17 beta HSD 4 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat, Hm |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | 17 beta HSD 4 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 744-761 of Human 17 beta HSD 4 (NIMLSQKLQMILKDYAKL). |
| Conjugation | Un-conjugated |
| Alternate Names | EC 1.1.1.n12; Multifunctional protein 2; Peroxisomal multifunctional enzyme type 2; SDR8C1; EC 4.2.1.107; 17-beta-HSD 4; 3R; MFE-2; PRLTS1; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; Short chain dehydrogenase/reductase family 8C member 1; 17-beta-hydroxysteroid dehydrogenase 4; DBP; MPF-2; EC 4.2.1.119; D-bifunctional protein |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: By heat mediation. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Thimerosal and 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P51659 Human Peroxisomal multifunctional enzyme type 2 |
|---|---|
| Gene Symbol | HSD17B4 |
| Gene Full Name | hydroxysteroid (17-beta) dehydrogenase 4 |
| Background | The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] |
| Function | Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. [UniProt] |
| Cellular Localization | Peroxisome. [UniProt] |
| Calculated MW | 80 kDa |
