ARG64410

anti-ACVR1 / ALK2 antibody

anti-ACVR1 / ALK2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

Developmental Biology antibody; Gene Regulation antibody; Signaling Transduction antibody

Overview

Product Description Goat Polyclonal antibody recognizes ACVR1 / ALK2
Tested Reactivity Hu
Predict Reactivity Ms, Rat, Dog
Tested Application IHC-P, WB
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name ACVR1 / ALK2
Antigen Species Human
Immunogen C-RKFKRRNQERLNPRD
Conjugation Un-conjugated
Alternate Names ALK2; ACTRI; FOP; Serine/threonine-protein kinase receptor R1; Activin receptor type I; EC 2.7.11.30; Activin receptor-like kinase 2; TSRI; ACVRLK2; Activin receptor type-1; SKR1; ACVR1A; ACTR-I; TGF-B superfamily receptor type I; TSR-I; ALK-2

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P4 - 6 µg/ml
WB0.3 - 1 µg/ml
Application Note IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0).
WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 90 Human ACVR1

Swiss-port # Q04771 Human Activin receptor type-1

Gene Symbol ACVR1
Gene Full Name activin A receptor type 1
Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
Research Area Developmental Biology antibody; Gene Regulation antibody; Signaling Transduction antibody
Calculated MW 57 kDa