ARG54803
anti-ACVRL1 antibody
anti-ACVRL1 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody
Overview
Product Description | Rabbit Polyclonal antibody recognizes ACVRL1 |
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Tested Reactivity | Hu, Ms |
Tested Application | FACS, IHC-P, WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | ACVRL1 |
Antigen Species | Human |
Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 38-68 (N-terminus) of Human ACVRL1. |
Conjugation | Un-conjugated |
Alternate Names | ACVRLK1; ALK1; ORW2; ALK-1; HHT; EC 2.7.11.30; Serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I; HHT2; SKR3; TSR-I; Activin receptor-like kinase 1 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
Positive Control | Mouse heart |
Properties
Form | Liquid |
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Purification | Purification with Protein G. |
Buffer | PBS and 0.09% (W/V) Sodium azide |
Preservative | 0.09% (W/V) Sodium azide |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # P37023 Human Serine/threonine-protein kinase receptor R3 Swiss-port # Q61288 Mouse Serine/threonine-protein kinase receptor R3 |
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Gene Symbol | ACVRL1 |
Gene Full Name | activin A receptor type II-like 1 |
Background | This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008] |
Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. [UniProt] |
Cellular Localization | Membrane; Single-pass type I membrane protein |
Research Area | Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody |
Calculated MW | 56 kDa |