ARG66299
anti-ADAM19 antibody
anti-ADAM19 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
Product Description | Goat Polyclonal antibody recognizes ADAM19 |
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Tested Reactivity | Hu |
Predict Reactivity | Cow, Dog, Pig |
Tested Application | IHC-P, WB |
Host | Goat |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | ADAM19 |
Antigen Species | Human |
Immunogen | Synthetic peptide around the internal region of Human ADAM19 (KIQCQSSEARPLESN). |
Conjugation | Un-conjugated |
Alternate Names | ADAM 19; FKSG34; EC 3.4.24.-; MADDAM; Disintegrin and metalloproteinase domain-containing protein 19; MLTNB; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker |
Application Instructions
Application Suggestion |
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Application Note | IHC-P: Antigen Retrieval: Boil tissue section in Citrate buffer (pH 6.0). WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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Observed Size | ~ 125 kDa (glycosylated) |
Properties
Form | Liquid |
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Purification | Affinity purification with immunogen. |
Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
Preservative | 0.02% Sodium azide |
Stabilizer | 0.5% BSA |
Concentration | 0.5 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # Q9H013 Human Disintegrin and metalloproteinase domain-containing protein 19 |
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Gene Symbol | ADAM19 |
Gene Full Name | ADAM metallopeptidase domain 19 |
Background | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013] |
Function | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). [UniProt] |
Calculated MW | 105 kDa |
PTM | The precursor is cleaved by a furin endopeptidase. [UniProt] |