ARG42215

anti-ADAM22 antibody

anti-ADAM22 antibody for Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes ADAM22
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ADAM22
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 223-400 of Human ADAM22 (NP_004185.1).
Conjugation Un-conjugated
Alternate Names MDC2; Disintegrin and metalloproteinase domain-containing protein 22; ADAM 22; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2; Metalloproteinase-disintegrin ADAM22-3

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:1000 - 1:4000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control Rat kidney
Observed Size ~ 100kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 11496 Mouse ADAM22

GeneID: 53616 Human ADAM22

Swiss-port # Q9P0K1 Human Disintegrin and metalloproteinase domain-containing protein 22

Swiss-port # Q9R1V6 Mouse Disintegrin and metalloproteinase domain-containing protein 22

Gene Symbol ADAM22
Gene Full Name ADAM metallopeptidase domain 22
Background This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants. [provided by RefSeq, Dec 2010]
Function Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. Cell projection, axon. [UniProt]
Calculated MW 100 kDa
PTM The precursor is cleaved by a furin endopeptidase. [UniProt]