ARG44303
anti-ADNP antibody
anti-ADNP antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ADNP |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ADNP |
| Antigen Species | Human |
| Immunogen | Synthetic peptide |
| Conjugation | Un-conjugated |
| Alternate Names | ADNP; Activity Dependent Neuroprotector Homeobox; ADNP1; Activity-Dependent Neuroprotective Protein; KIAA0784; Activity-Dependent Neuroprotector Homeobox Protein |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified |
| Buffer | PBS with 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9H2P0 Human Activity-dependent neuroprotector homeobox protein |
|---|---|
| Gene Symbol | ADNP |
| Gene Full Name | Activity Dependent Neuroprotector Homeobox |
| Background | Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. |
| Function | May be involved in transcriptional regulation. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Positively modulates WNT-beta-catenin/CTNN1B signaling, acting by regulating phosphorylation of, and thereby stabilizing, CTNNB1. May be required for neural induction and neuronal differentiation. May be involved in erythroid differentiation. |
| Cellular Localization | Chromosome, Nucleus |
| Calculated MW | 124 kDa |
| PTM | Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation |
