ARG44619
anti-AGR3 antibody
anti-AGR3 antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes AGR3 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, IP |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | AGR3 |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | AGR3; Anterior Gradient 3, Protein Disulphide Isomerase Family Member; BCMP11; PDIA18; HAG-3; Protein Disulfide Isomerase Family A, Member 18; Breast Cancer Membrane Protein 11; HAG3; Anterior Gradient Protein 3; AG-3; AG3; Anterior Gradient 3 Homolog (Xenopus Laevis); Anterior Gradient Protein 3 Homolog; Anterior Gradient Homolog 3; Anterior Gradient 3 Homolog |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | AGR3 |
| Gene Full Name | Anterior Gradient 3, Protein Disulphide Isomerase Family Member |
| Background | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016] |
| Function | Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells. [UniProt] |
| Cellular Localization | Endoplasmic reticulum. [UniProt] |
| Calculated MW | 19 kDa |
