ARG58186
anti-ALAS1 antibody
anti-ALAS1 antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ALAS1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ALAS1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human Alas1. |
| Conjugation | Un-conjugated |
| Alternate Names | Delta-aminolevulinate synthase 1; 5-aminolevulinic acid synthase 1; ALASH; Delta-ALA synthase 1; ALAS3; 5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS-H; MIG4; ALAS; EC 2.3.1.37 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HepG2 | ||||||
| Observed Size | ~ 71 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P13196 Human 5-aminolevulinate synthase, nonspecific, mitochondrial |
|---|---|
| Gene Symbol | ALAS1 |
| Gene Full Name | 5'-aminolevulinate synthase 1 |
| Background | This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] |
| Cellular Localization | Mitochondrion matrix. [UniProt] |
| Calculated MW | 71 kDa |
