ARG59775
anti-ALDH4A1 antibody
anti-ALDH4A1 antibody for Western blot,ICC/IF and Human,Mouse
Overview
Product Description | Rabbit Polyclonal antibody recognizes ALDH4A1 |
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Tested Reactivity | Hu, Ms |
Tested Application | ICC/IF, WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | ALDH4A1 |
Antigen Species | Human |
Immunogen | Recombinant fusion protein corresponding to aa. 354-563 of Human ALDH4A1 (NP_003739.2). |
Conjugation | Un-conjugated |
Alternate Names | P5CD; ALDH4; P5CDh; Aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenase; Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; P5C dehydrogenase; EC 1.2.1.88 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
Positive Control | Mouse skeletal muscle and BT474 | ||||||
Observed Size | 65 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # P30038 Human Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial Swiss-port # Q8CHT0 Mouse Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial |
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Gene Symbol | ALDH4A1 |
Gene Full Name | aldehyde dehydrogenase 4 family, member A1 |
Background | This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009] |
Function | Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. [UniProt] |
Cellular Localization | Mitochondrion matrix. [UniProt] |
Calculated MW | 62 kDa |