ARG57318
anti-ALKBH7 antibody
anti-ALKBH7 antibody for Western blot and Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ALKBH7 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ALKBH7 |
| Antigen Species | Human |
| Immunogen | Recombinant Protein of Human ALKBH7. |
| Conjugation | Un-conjugated |
| Alternate Names | Spermatogenesis-associated protein 11; SPATA11; UNQ6002; Alkylated DNA repair protein alkB homolog 7; ABH7; EC 1.14.11.-; Spermatogenesis cell proliferation-related protein; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Mouse eye |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9D6Z0 Mouse Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial |
|---|---|
| Gene Symbol | ALKBH7 |
| Gene Full Name | alkB, alkylation repair homolog 7 (E. coli) |
| Function | May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity). [UniProt] |
| Calculated MW | 25 kDa |
