ARG44342
anti-ANKH antibody
anti-ANKH antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ANKH |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ANKH |
| Antigen Species | Human |
| Immunogen | Human ANKH recombinant fusion protein (a.a. sequence: 210-320). |
| Conjugation | Un-conjugated |
| Alternate Names | ANKH; ANKH Inorganic Pyrophosphate Transport Regulator; ANK; SLC62A1; CPPDD; HANK; Progressive Ankylosis Protein Homolog; Mineralization Regulator ANKH; ATP Carrier Protein ANKH; CCAL2; CMDJ; Craniometaphyseal Dysplasia, Jackson Type (Dominant); Ankylosis, Progressive (Mouse) Homolog; Ankylosis, Progressive Homolog (Mouse); Ankylosis, Progressive Homolog; KIAA1581; MANK |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS, 0.02% sodium azide and 50% Glycerol. |
| Preservative | 0.02% sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9HCJ1 Human Progressive ankylosis protein homolog |
|---|---|
| Gene Symbol | ANKH |
| Gene Full Name | ANKH Inorganic Pyrophosphate Transport Regulator |
| Background | This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. |
| Function | Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. |
| Cellular Localization | Cell membrane, Membrane |
| Calculated MW | 54 kDa |
