ARG59798
anti-AP3B1 / HPS2 antibody
anti-AP3B1 / HPS2 antibody for Western blot and Human,Mouse
Overview
Product Description | Rabbit Polyclonal antibody recognizes AP3B1 / HPS2 |
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Tested Reactivity | Hu, Ms |
Tested Application | WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | AP3B1 / HPS2 |
Antigen Species | Human |
Immunogen | Recombinant fusion protein corresponding to aa. 895-1094 of Human AP3B1 (NP_003655.3). |
Conjugation | Un-conjugated |
Alternate Names | Adaptor-related protein complex 3 subunit beta-1; AP-3 complex subunit beta-1; HPS; ADTB3A; Clathrin assembly protein complex 3 beta-1 large chain; Adaptor protein complex AP-3 subunit beta-1; ADTB3; HPS2; PE; Beta-3A-adaptin |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
Positive Control | Mouse liver and SW620 | ||||
Observed Size | 132 kDa |
Properties
Form | Liquid |
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Purification | Affinity purified. |
Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 50% Glycerol |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | AP3B1 |
Gene Full Name | adaptor-related protein complex 3, beta 1 subunit |
Background | This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012] |
Function | Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [UniProt] |
Cellular Localization | Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. [UniProt] |
Calculated MW | 121 kDa |
PTM | Phosphorylated on serine residues. [UniProt] |