ARG44015
anti-ARMET antibody
anti-ARMET antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ARMET |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ARMET |
| Antigen Species | Human |
| Immunogen | Human ARMET recombinantprotein |
| Conjugation | Un-conjugated |
| Protein Full Name | Mesencephalic astrocyte-derived neurotrophic factor |
| Alternate Names | MANF; Mesencephalic Astrocyte Derived Neurotrophic Factor; ARP; Mesencephalic Astrocyte-Derived Neurotrophic Factor; ARMET; Arginine-Rich, Mutated In Early Stage Tumors; Arginine-Rich Protein; Protein ARMET |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purified. |
| Buffer | PBS containing 0.02% sodium azide |
| Preservative | 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P0C5H9 Rat Mesencephalic astrocyte-derived neurotrophic factor Swiss-port # P55145 Human Mesencephalic astrocyte-derived neurotrophic factor |
|---|---|
| Gene Symbol | MANF |
| Gene Full Name | Mesencephalic Astrocyte Derived Neurotrophic Factor |
| Background | The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. |
| Function | Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. |
| Cellular Localization | Endoplasmic reticulum, Sarcoplasmic reticulum, Secreted |
| Calculated MW | 20 kDa |
| PTM | Disulfide bond, Glycoprotein, Phosphoprotein |
