ARG54433
anti-ARTS antibody
anti-ARTS antibody for Immunohistochemistry,Western blot and Human
Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ARTS |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC, WB |
| Specificity | This antibody recognizes human ARTS (Apoptosis Related Protein in TGF- Signaling Pathway), a novel mito-chondrial septin-like protein. ARTS translocates to the cell nucleus when apoptosis occurs. It enhances apoptosis induced by TGF- and other inducers of apoptosis, such as TNF- and Fas ligand. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ARTS |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around aa. 3-14 of Human ARTS. |
| Conjugation | Un-conjugated |
| Alternate Names | Apoptosis-related protein in the TGF-beta signaling pathway; PNUTL2; ARTS; Peanut-like protein 2; Cell division control-related protein 2; CE5B3; Brain protein H5; CE5B3 beta; Septin-4; BRADEION; H5; MART; Bradeion beta; hucep-7; hCDCREL-2; SEP4; Cerebral protein 7 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Human lung, kidney and spleen |
Properties
| Form | Liquid |
|---|---|
| Purification | Immunoaffinity chroma-tography |
| Buffer | PBS (pH 7.4) and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P60891 Human Ribose-phosphate pyrophosphokinase 1 |
|---|---|
| Gene Symbol | SEPT4 |
| Gene Full Name | septin 4 |
| Background | This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010] |
| Function | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. [UniProt] |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody |
| Calculated MW | 55 kDa |
