ARG58362

anti-ATP1A2 / Na+ K+ ATPase alpha 2 antibody

anti-ATP1A2 / Na+ K+ ATPase alpha 2 antibody for Western blot and Human,Mouse,Rat

Overview

Product Description Rabbit Polyclonal antibody recognizes ATP1A2 / Na+ K+ ATPase alpha 2
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name ATP1A2 / Na+ K+ ATPase alpha 2
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 1-70 of Human ATP1A2 (NP_000693.1).
Conjugation Un-conjugated
Alternate Names MHP2; Sodium pump subunit alpha-2; Sodium/potassium-transporting ATPase subunit alpha-2; EC 3.6.3.9; FHM2; Na+ K+ ATPase alpha 2; Na K ATPase alpha 2; sodium potassium ATPase alpha 2; ATPase Na+ K+ alpha 2; ATPase Na K alpha 2; ATPase sodium potassium alpha 2

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control OVCAR3
Observed Size 112 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 24212 Rat ATP1A2

GeneID: 477 Human ATP1A2

GeneID: 98660 Mouse ATP1A2

Gene Symbol ATP1A2
Gene Full Name ATPase, Na+/K+ transporting, alpha 2 polypeptide
Background The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]
Function This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. [UniProt]
Cellular Localization Cell membrane, Membrane, Multi-pass membrane protein. [UniProt]
Calculated MW 112 kDa