ARG55557
anti-ATP1B2 / Na+ K+ ATPase beta 2 antibody
anti-ATP1B2 / Na+ K+ ATPase beta 2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Signaling Transduction antibody
Overview
Product Description | Rabbit Polyclonal antibody recognizes ATP1B2 / Na+ K+ ATPase beta 2 |
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Tested Reactivity | Hu, Ms |
Predict Reactivity | Bov, Rb |
Tested Application | FACS, IHC-P, WB |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | ATP1B2 / Na+ K+ ATPase beta 2 |
Antigen Species | Human |
Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 115-141 (Center) of Human Na+ K+ ATPase beta 2. |
Conjugation | Un-conjugated |
Alternate Names | Sodium/potassium-dependent ATPase subunit beta-2; Sodium/potassium-transporting ATPase subunit beta-2; AMOG; Adhesion molecule in glia; adhesion molecule on glia; AT1B2; ATPB2; ATPB2S; Na+ K+ ATPase beta 2; Na K ATPase beta 2; sodium potassium ATPase beta 2; ATPase Na+ K+ beta 2; ATPase Na K beta 2; ATPase sodium potassium beta 2 |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
Positive Control | Human brain |
Properties
Form | Liquid |
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Purification | Purification with Protein A and immunogen peptide. |
Buffer | PBS and 0.09% (W/V) Sodium azide |
Preservative | 0.09% (W/V) Sodium azide |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links |
Swiss-port # P14231 Mouse Sodium/potassium-transporting ATPase subunit beta-2 Swiss-port # P14415 Human Sodium/potassium-transporting ATPase subunit beta-2 |
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Gene Symbol | ATP1B2 |
Gene Full Name | ATPase, Na+/K+ transporting, beta 2 polypeptide |
Background | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] |
Function | This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth. [UniProt] |
Cellular Localization | Cell membrane; Single-pass type II membrane protein |
Research Area | Signaling Transduction antibody |
Calculated MW | 33 kDa |