ARG59563

anti-Acetyl CoA carboxylase 1 antibody

anti-Acetyl CoA carboxylase 1 antibody for Western blot and Human,Mouse,Rat

Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody; AMPK-ACC pathway antibody

Overview

Product Description Rabbit Polyclonal antibody recognizes Acetyl CoA carboxylase 1
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Acetyl CoA carboxylase 1
Antigen Species Human
Immunogen Synthetic peptide of Human Acetyl CoA carboxylase 1.
Conjugation Un-conjugated
Alternate Names ACC; ACACAD; Acetyl-CoA carboxylase 1; ACAC; EC 6.4.1.2; ACCA; EC 6.3.4.14; ACC-alpha; ACC1

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500 - 1:2000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control C6, HeLa and C2C12.
Observed Size 240 kDa

Properties

Form Liquid
Purification Affinity purified.
Buffer PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative 0.02% Sodium azide
Stabilizer 50% Glycerol
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 107476 Mouse ACACA

GeneID: 31 Human ACACA

GeneID: 60581 Rat ACACA

Gene Symbol ACACA
Gene Full Name acetyl-CoA carboxylase alpha
Background Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. [UniProt]
Cellular Localization Cytoplasm. [UniProt]
Research Area Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody; AMPK-ACC pathway antibody
Calculated MW 266 kDa
PTM Phosphorylation on Ser-1263 is required for interaction with BRCA1. [UniProt]