ARG11121
anti-Adenylate cyclase 3 antibody [1A12]
anti-Adenylate cyclase 3 antibody [1A12] for IHC-Frozen sections and Rat
Overview
| Product Description | Mouse Monoclonal antibody [1A12] recognizes Adenylate cyclase 3 |
|---|---|
| Tested Reactivity | Rat |
| Predict Reactivity | Hu, Ms |
| Tested Application | IHC-Fr |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 1A12 |
| Isotype | IgG1 |
| Target Name | Adenylate cyclase 3 |
| Antigen Species | Rat |
| Immunogen | KLH-conjugated synthetic peptide around the C-terminal region of Rat Adenylate cyclase 3. (C-PAAFPNGSSVTLPHQVVDNP) |
| Conjugation | Un-conjugated |
| Alternate Names | AC-III; Adenylate cyclase type III; AC3; ATP pyrophosphate-lyase 3; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; EC 4.6.1.1; Adenylate cyclase type 3 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified |
| Buffer | PBS, 5 mM Sodium azide and 50% Glycerol. |
| Preservative | 5 mM Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ADCY3 |
| Gene Full Name | adenylate cyclase 3 |
| Background | This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. [UniProt] |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus. Note=Also detected in the cytoplasm, close to lipid droplets. [UniProt] |
| Calculated MW | 129 kDa |
| PTM | Sumoylated. Sumoylation is required for targeting ot olfactory cilia. N-glycosylated. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG11121 anti-Adenylate cyclase 3 antibody [1A12] IHC-Fr image
Immunohistochemistry: Frozen section of caudate/putamen region of rat brain stained with ARG11121 anti-Adenylate cyclase 3 antibody [1A12] (red), and co-stained with anti-Tyrosine Hydroxylase antibody (green). Hoechst (blue) for nuclear staining.
