ARG55263
anti-Annexin A1 antibody
anti-Annexin A1 antibody for Western blot and Human,Mouse,Rat,Monkey
Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody recognizes Annexin A1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat, Mk |
| Tested Application | WB |
| Specificity | This antibody detects endogenous levels of Annexin A1 and does not cross-react with related proteins. |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | Annexin A1 |
| Antigen Species | Human |
| Immunogen | Purified recombinant fragment of Human Annexin A1 (NP_000691.1). |
| Conjugation | Un-conjugated |
| Alternate Names | ANX1; Calpactin II; Phospholipase A2 inhibitory protein; Chromobindin-9; LPC1; Annexin-1; Annexin A1; Lipocortin I; Annexin I; p35; Calpactin-2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.4), 0.03% Proclin 300 and 50% Glycerol |
| Preservative | 0.03% Proclin 300 |
| Stabilizer | 50% Glycerol |
| Concentration | 4.85 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ANXA1 |
| Gene Full Name | annexin A1 |
| Background | This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014] |
| Function | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity. [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm. Cell projection > cilium. Basolateral cell membrane. [UniProt] |
| Research Area | Signaling Transduction antibody |
| Calculated MW | 39 kDa |
| PTM | Phosphorylated by protein kinase C, EGFR and TRPM7 (PubMed:2457390, PubMed:15485879). Phosphorylated in response to EGF treatment (PubMed:2532504). Sumoylated. |
