ARG65669

anti-Annexin A2 antibody

anti-Annexin A2 antibody for Western blot and Human,Mouse

Signaling Transduction antibody

Overview

Product Description

Goat Polyclonal antibody recognizes Annexin A2

Tested Reactivity Hu, Ms
Predict Reactivity Cow, Rat, Pig
Tested Application WB
Specificity This antibody is expected to recognise both reported isoforms. NP_004030.1, NP_001002857.1 and NP_001129487.1 are varients of isoform 2.
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name Annexin A2
Antigen Species Human
Immunogen Synthetic peptide around the N-terminus of Human Annexin A2 (STVHEILCKLSLEGD)
Conjugation Un-conjugated
Alternate Names Placental anticoagulant protein IV; LPC2; Protein I; Calpactin-1 heavy chain; Calpactin I heavy chain; p36; CAL1H; ANX2; LPC2D; Lipocortin II; ANX2L4; HEL-S-270; LIP2; Annexin II; Annexin A2; Annexin-2; P36; Chromobindin-8; PAP-IV

Application Instructions

Application Suggestion
Tested Application Dilution
WB0.5 - 3 µg/ml
Application Note WB: Recommend incubate at RT for 1h.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 12306 Mouse ANXA2

GeneID: 302 Human ANXA2

Swiss-port # P07355 Human Annexin A2

Swiss-port # P07356 Mouse Annexin A2

Gene Symbol ANXA2
Gene Full Name annexin A2
Background This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 [UniProt]
Research Area Signaling Transduction antibody
Calculated MW 39 kDa
PTM Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
ISGylated.