ARG65669
anti-Annexin A2 antibody
anti-Annexin A2 antibody for Western blot and Human,Mouse
Signaling Transduction antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes Annexin A2 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Predict Reactivity | Cow, Rat, Pig |
| Tested Application | WB |
| Specificity | This antibody is expected to recognise both reported isoforms. NP_004030.1, NP_001002857.1 and NP_001129487.1 are varients of isoform 2. |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | Annexin A2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide around the N-terminus of Human Annexin A2 (STVHEILCKLSLEGD) |
| Conjugation | Un-conjugated |
| Alternate Names | Placental anticoagulant protein IV; LPC2; Protein I; Calpactin-1 heavy chain; Calpactin I heavy chain; p36; CAL1H; ANX2; LPC2D; Lipocortin II; ANX2L4; HEL-S-270; LIP2; Annexin II; Annexin A2; Annexin-2; P36; Chromobindin-8; PAP-IV |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ANXA2 |
| Gene Full Name | annexin A2 |
| Background | This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 [UniProt] |
| Research Area | Signaling Transduction antibody |
| Calculated MW | 39 kDa |
| PTM | Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. ISGylated. |
