ARG23528

anti-Apolipoprotein H antibody [ID2]

anti-Apolipoprotein H antibody [ID2] for IHC-Frozen sections,Western blot and Human

Overview

Product Description Mouse Monoclonal antibody [ID2] recognizes Apolipoprotein H.
Mouse anti Human apolipoprotein H antibody, clone 1D2 recognizes the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1, APC inhibitor, activated protein C-binding protein or anticardiolipin cofactor. Apolipoprotein H is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, a process involved in the pathogenesis of recurrent miscarriage and thrombotic tendencies due to antiphospholipid syndrome.
Tested Reactivity Hu
Tested Application IHC-Fr, WB
Host Mouse
Clonality Monoclonal
Clone ID2
Isotype IgG1
Target Name Apolipoprotein H
Antigen Species Human
Conjugation Un-conjugated
Alternate Names Apo-H; Beta-2-glycoprotein 1; BG; B2G1; APC inhibitor; Apolipoprotein H; Anticardiolipin cofactor; B2GPI; Beta; 2; Activated protein C-binding protein; B2GP1; Beta-2-glycoprotein I

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-FrAssay-dependent
WBAssay-dependent
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Tissue Culture Supernatant
Buffer Tissue Culture Supernatant and 0.09% Sodium azide.
Preservative 0.09% Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 350 Human APOH

Swiss-port # P02749 Human Beta-2-glycoprotein 1

Gene Symbol APOH
Gene Full Name apolipoprotein H (beta-2-glycoprotein I)
Background Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
Function Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. [UniProt]
Calculated MW 38 kDa
PTM N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele. [UniProt]