ARG23528
anti-Apolipoprotein H antibody [ID2]
anti-Apolipoprotein H antibody [ID2] for IHC-Frozen sections,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [ID2] recognizes Apolipoprotein H. Mouse anti Human apolipoprotein H antibody, clone 1D2 recognizes the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1, APC inhibitor, activated protein C-binding protein or anticardiolipin cofactor. Apolipoprotein H is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, a process involved in the pathogenesis of recurrent miscarriage and thrombotic tendencies due to antiphospholipid syndrome. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-Fr, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ID2 |
| Isotype | IgG1 |
| Target Name | Apolipoprotein H |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | Apo-H; Beta-2-glycoprotein 1; BG; B2G1; APC inhibitor; Apolipoprotein H; Anticardiolipin cofactor; B2GPI; Beta; 2; Activated protein C-binding protein; B2GP1; Beta-2-glycoprotein I |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
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| Purification | Tissue Culture Supernatant |
| Buffer | Tissue Culture Supernatant and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
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| Gene Symbol | APOH |
| Gene Full Name | apolipoprotein H (beta-2-glycoprotein I) |
| Background | Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008] |
| Function | Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. [UniProt] |
| Calculated MW | 38 kDa |
| PTM | N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele. [UniProt] |
