ARG23488
anti-Aquaporin 1 antibody [7D11]
anti-Aquaporin 1 antibody [7D11] for ELISA,Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [7D11] recognizes Aquaporin 1. Mouse anti Aquaporin 1 antibody, clone 7D11 recognizes an epitope within an extracellular region of the water-specific channel aquaporin 1 (also known as AQP1 or CHIP-28)Aquaporin 1 is a 28kDa integral membrane protein which was originally identified in red blood cells and renal proximal tubules. AQP1 is also expressed by the choroid plexus and various other tissues. The glycosylated forms of AQP1 range between 40-60kDa in mass. |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ELISA, FACS, IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 7D11 |
| Isotype | IgG2b |
| Target Name | Aquaporin 1 |
| Antigen Species | Rat |
| Immunogen | Synthetic peptide around aa. 198-208 of Rat Aquaporin 1. |
| Conjugation | Un-conjugated |
| Alternate Names | Aquaporin-1; CO; AQP-CHIP; AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule; CHIP28; Urine water channel |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Boil tissue section in Sodium citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS, 0.1% Sodium azide and 0.1% BSA. |
| Preservative | 0.1% Sodium azide |
| Stabilizer | 0.1% BSA |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
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| Gene Symbol | AQP1 |
| Gene Full Name | aquaporin 1 (Colton blood group) |
| Background | Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| Function | Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. [UniProt] |
| Calculated MW | 29 kDa |
