ARG54594
anti-BCMA antibody
anti-BCMA antibody for Western blot and Human
Cancer antibody; Immune System antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes BCMA |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Specificity | This antibody recognizes human BCMA(B Cell Maturation Protein). BCMA is areceptor for BAFF and April, two novelmembers of the TNF superfamily ofproteins regulating immune responseand the induction of apoptosis throughthe activation of NF-κB and c-jun Nterminalkinase. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | BCMA |
| Antigen Species | Human |
| Immunogen | A synthetic peptide corresponding to the C-terminus of Human BCMA. |
| Conjugation | Un-conjugated |
| Alternate Names | BCM; BCMA; CD269; CD antigen CD269; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; TNFRSF13A |
Application Instructions
| Application Note | Western blot: Use at 2 - 5 ug/ml. A band of approximately 27 kD is detected using K562 cell lysate as a positive control. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|---|
| Positive Control | K562 |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.4) and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q02223 Human Tumor necrosis factor receptor superfamily member 17 |
|---|---|
| Gene Symbol | TNFRSF17 |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 17 |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008] |
| Function | Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. [UniProt] |
| Research Area | Cancer antibody; Immune System antibody; Signaling Transduction antibody |
| Calculated MW | 20 kDa |
